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Muscle involvement in leprosy: study of the anterior tibial muscle in 40 patients

机译:麻风肌受累:40例胫前肌的研究

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The involvement of skeletal striated muscle in leprosy is considered secondary due to peripheral neuropathy, but some studies point it to a primary muscle lesion. In order to investigate the muscle involvement in leprosy, we studied 40 patients (lepromatous 23, tuberculoid 13, borderline 2 and indeterminate 2). The motor nerve conduction of the peroneal nerves had a reduction of the velocity, decreased compound muscle action potential and sometimes absence of potentials. The electromyographic study of the anterior tibial muscle showed signs of recent and chronic denervation in 77.5% of the cases and no myopathic potentials. The anterior tibial muscle biopsy revealed denervation in 45% of the cases, interstitial inflammatory myopathy in 30% and mixed (myopathic and neuropathic) pattern in 12.5%. Acid fast bacillus was detected in 25% of the cases, always in the interstitial tissue. Inflammatory reaction was present in the interstitial space and in patients with the lepromatous type. The histological findings clearly defined the presence of the so-called "Leprous Interstitial Myositis" on the top of denervation signs.
机译:由于周围神经病变,麻风中的骨骼肌横纹肌受累被认为是继发性的,但一些研究指出它是原发性肌肉病变。为了研究麻风病的肌肉受累情况,我们研究了40例患者(麻风23例,结核13例,交界2例和不确定2例)。腓神经的运动神经传导降低了速度,降低了复合肌肉动作电位,有时甚至没有电位。胫骨前肌的肌电图研究显示77.5%的病例有近期和慢性神经支配的体征,无肌病性电位。胫骨前肌活检显示神经支配率为45%,间质性炎症性肌病为30%,混合(肌病和神经病变)为12.5%。 25%的病例总是在间质组织中检测到耐酸杆菌。间质间隙和麻风病患者存在炎症反应。组织学检查结果清楚地定义了去神经支配体征上方存在所谓的“麻风间质性肌炎”。

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