Inhibition of cryoglobulin synthesis as an effective method of positive influence on spermogram indices

摘要

Background Clinical signs of cryoglobulinemia syndrome depend on localization of affected vessels, and vascular pathology is a frequent cause of sexual disorders. Thus, the article presents correlation between cryoglobulinemia and spermatogenesis impairment. Aims The aim of our investigation was to study reference between cryoglobulinemia and spermatogenesis impairment. The method of intradermal autoleukocyte immunization was used for inhibition of cryoglobulin synthesis. Methods The research involved patients with idiopathic oligoasthenoteratozoospermia and various severe forms of infertility, when cryoglobulinemia of the 2nd and 3rd types was detected. Leukocytes for immunization were isolated from plasma of a patient’s heparinized venous blood by centrifuging at 400g for 8 minutes, after that the residue was resuspended in 1–1.5ml of own blood serum and injected intradermally in 0.1ml dose into the back. Spermogram indices were compared before and in 10–15 days after immunization. Results In most patients (75.0 per cent) with idiopathic oligoasthenoteratozoospermia and cryoglobulinemia, spermogram indices completely returned to norm due to inhibition of cryoglobulin synthesis. In men with severe forms of infertility, elimination of cryoglobulins also had a positive impact on spermatogenesis (100 per cent), which resulted in normalization of spermogram indices and improved the conditions for assisted reproductive technologies. Conclusion The results of investigation indicate that a considerable reduction of cryoglobulinemia has a positive impact on spermatogenesis. Therefore, it is expedient to include the method for detection of cryoglobulins into methodical recommendations/instructions for examination of patients with impairment of male fertility. Immunization with own leukocytes is recommended for inhibition of cryoglobulin synthesis.