ANTIDIABETIC EFFECTS OF INDONESIAN BAY LEAVES (SYZYGIUM POLYANTHUM) EXTRACTS THROUGH DECREASING ADVANCED GLYCATION END PRODUCTS AND BLOOD GLUCOSE LEVEL ON ALLOXAN-INDUCED HYPERGLYCEMIC WISTAR RATS

摘要

Objective: Increased production of reactive oxygen species is one of the causes of hyperglycemia. This study aims to determine the effectiveness of Indonesian bay leaves ( Syzygium polyanthum ) extracts as an antidiabetic agent in decreasing blood glucose and advanced glycation end products (AGEs) level of alloxan-induced hyperglycemic Wistar rats. Methods: This research is a real experimental study with pre- and post-test control group design. The study begins with the induction of hyperglycemia in 40 Wistar rats using alloxan. Subsequently, hyperglycemic rats were divided into 6 groups, namely, the positive control group (P0); the treatment group by not giving the intake of Indonesian bay leaf (P1); the treatment group was given the extract of Indonesian bay leaves ( S. polyanthum ) 0.5 mg/kg body weight/day (P2); treatment group given Indonesian bay leaves extract 2.0 mg/kg body weight/day (P3); treatment group given Indonesian bay leaves 5.0 mg/kg body weight/day (P4), and P5 was treatment group with glibenclamide (hyperglycemia-lowering medication). Results: In the treatment of P1, P2, P3, P4, and P5 groups, it can be seen that there are decreases of blood glucose and AGEs level between pre- and post-test comparison. However, the most significant drop in mean plasma glucose level was observed at the dosage 5.0 mg kg-1 (P4). Conclusion: The administration of Indonesian bay leaf extracts at a dose of 5.0 mg/kg body weight/day have an antidiabetic effect through decreasing blood glucose and AGEs level in alloxan-induced hyperglycemic Wistar rats.