EFFECT OF ETHANOL EXTRACT OF PICRIA FEL-TERRAE LOUR. LEAVES ON TRIGLYCERIDE AND CHOLESTEROL LEVELS OF WHITE RATS

摘要

Objective: The objective of the study was to evaluate the effect of Picria fel-terrae on triglyceride and cholesterol levels in long-term duration. Methods: The effect of ethanol extract of P. fel-terrae leaves was performed using white rats divided into several groups, which include control group, extract at doses of 125, 250, 500, and 1000 mg/kg body weight. The extract at different doses was orally administered to the test animal for 90 days. Then, the triglyceride and cholesterol levels were measured. Results: The ethanol extract of P. fel-terrae in long-term use did not affect the cholesterol level of male and female white rats. However, there was a significant increased in triglyceride level as compared to normal control (p<0.05). Conclusion: The ethanol extract of P. fel-terrae increased triglyceride level only without increasing the level of cholesterol.