STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE

摘要

Objective: A study which involves in detecting anticonvulsant activity from Anacyclus pyrethrum roots by using maximal electroshock seizure (MES)in a dose-dependent way with the production of ethanolic extraction.Methods: The MES test is considered to be a predictor of likely therapeutic efficacy against generalized tonic-clonic seizures.Results: MES-induced tonic seizures can be prevented either by drugs that inhibit voltage dependent Na+ channels, such as phenytoin, valproate, andlamotrigine or by drugs that block glutamatergic excitation mediated by the N-methyl-D-aspartate receptor like felbamate.Conclusion: The efficiency of A. pyrethrum will be detected after the incubation time of the animal, and the values of the ethanolic extraction will betested for the anticonvulsant activity.