EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF LEUCAS ASPERA HYDROALCOHOLIC LEAF EXTRACT DURING EXPOSURE TO LEAD ACETATE IN MALE ALBINO WISTAR RATS

摘要

The objective of the present study is to evaluate hepatoprotective activity of hydroalcoholic leaf extract of Leucas aspera on male albino wistar rats. Hepatoprotective activity of hydroalcoholic leaf extract of Leucas aspera on male albino wistar rats at a dose of 400 mg/kg was evaluated during exposure to lead acetate at a oral dose of 50 mg/kg. Male albino wistar rats of 6 numbers in each group was undertaken for study and evaluated by liver function test. A dose of 400 mg/ kg hydroalcoholic leaf extract of Leucas aspera showed a significant reduction in the liver enzymes (P< 0.05) in the dose dependent manner. Hence the hydroalcoholic leaf extract of Leucas aspera have shown hepatoprotective activity