EFFECT OF HYDROPHOBIC EXCIPIENTS ON RELEASE KINETICS OF CIPROFLOXACIN FROM KOLLIDON? SR EMBEDDED MATRIX TABLETS

摘要

Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Kollidon. SR as a matrix former and different hydrophobic excipients as release modifier. Six hydrophobic excipients: glyceryl monostearate, glyceryl palmitostearate, glyceryl dibehenate, cetyl alcohol, stearic acid and bees wax were used at 10% and 20% level in the matrix systems. Prepared tablets showed good tabletting prope rties. In vitro dissolution study was carried out in 0.01 N HCl solutions for 10 hours. Matrix systems consisting of 20% of the hydrophobic excipients showed more release retarding capacity than those consisting of 10% level o f the excipients. In case of 20% level of the excipients, ciprofloxacin release was 64% for glyceryl monostearate, 60% for glyceryl palmitostearate, 68% for glyceryl dibehenate, 52% for cetyl alcohol, 74% for stearic acid and 94% for bees wax. Drug release from the matrix systems followed non-fickian or anomalous mechanism