IN VITRO ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS LINN. LEAVES EXTRACTS

摘要

The present laboratory study was carried out to investigate the anthelmintic properties of Ficus benghalensis Linn leaves extracts against Indian earthworms Pheretima posthuma. Alcoholic extract and aqueous extract of leaves were used as test solutions. Albendazole was included as standard drug and normal saline as control. Observations were made for the time taken to paralyze and death of the earthworm. Three co ncentrations 25mg/ml, 50mg/ml, 100mg/ml of each extract and standard drug at the concentration of 25mg/ml were studied. The results of study indicated that Ficus benghalensis Linn leaves extracts exhibited anthelmintic activity significantly in a dose dependent manner when compared with standard group. For the aqueous extract group the time of paralysis and death time was 3.92 minute and 13.72 minute, while alcoholic e xtract group showed shortest time of paralysis (P) at 2.12 minute and death (D) at 7.34 minute of earthwo rms at higher concentration 100mg/ml as compared to standard Albendazole (25mg/ml) paralysis 2.36 minute and death at 6.42 minute respectively. Alcoholic extract showed more pro nounced effect than aqueous extract. Whereas the control group worms were observed for full day and night and there was no paralysis or death was found during that period