Neuroprotective effect of quercetin in neurotoxicity induced rats: role of neuroinflammation in neurodegeneration

摘要

Objective: To study the neuroprotective effect of quercetin in animal model of neurodegeneration. Methods: Quercetin (3,5,7,3’,4’- pentahydroxy flavones) is a potential compound having both anti-inflammatory and anti-oxidant properties with low gastric and cardiac side effect. Different COX-2 inhibitors like nimesulide, refecoxib and celecoxib have been proved to have their neuroprotective action in different animal models of neurodegenerative disorders but they are burdened with high toxicity. Different neurodegenerative models like haloperidol induced catalepsy, Reserpine induced vacuous chewing movements and MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)induced neurodegeneration were evaluated with Levadopa at a dose of (30 mg/kg i.p.) and Quercetin at a dose of (25 mg/kg, p.o.) as standard and test drugs respectively. Results: In the haloperidol induced catalepsy model the increased cataleptic score was significantly reduced with both the standard drug Levodopa and the test drug Quercetin. The increased frequencies of vacuous chewing movements on administration of Reserpine were reversed with the treatment of Quercetin. The reduced actophotometer activity score due to Reserpine was significantly reversed by Quercetin. The decreased level of lipid per-oxidation and increased glutathione concentration by the administration of Quercetin which reversed the toxicity of MPTP. Conclusion: Quercetin is a potential compound having both anti-inflammatory and anti-oxidant properties. These effects of enlights the pharmacodynamic pathway of neuroprotective properties of Quercetin in animal model study.