EVALUATION OF ANTHELMINTIC ACTIVITY OF PRUNUS PERSICA (L.)

摘要

Objective: Prunus persica leaves are used as anthelmintic, insecticidal, sedative, diuretic, demulcent, expectorant and vermicidal ethnopharmacologically. Objective of present study was evaluation of anthelmintic activity of different extracts of Prunus persica leaves. Methods: Pheretima posthuma (annelids) and Ascaridia galli (nematods) were used to perform experiments for anthelmintic activity. Piperazine citrate was used as standard. Time required for paralysis and death (lethal time) of worms were noted for each sample of P. persica extracts and standard. Results: The results demonstrated that treatment with Prunus persica significantly ( P <0.05- P <0.01) with dose-dependently paralyzed and killed the both A. galli and earthworms. Ethanol and ethyl acetate extracts have showed comparable anthelmintic activity at the highest concentration (60 mg/ml) to the well known anthelmintic agent Piperazine citrate against A. galli . Conclusion: The ethanolic & ethyl acetate extracts exhibited maximum potency i.e. shortest paralysis and lethal times. The potency was not more than the reference drug, piperazine citrate but comparable to it at 60 mg/ml concentrations in both test worms.