Dexamethasone combined with other antiemetics for prophylaxis after laparoscopic cholecystectomy

摘要

Summary Background/Objective Postoperative nausea and vomiting (PONV) is one of the most common and distressing adverse events after laparoscopic cholecystectomy (LC). A meta-analysis of randomized clinical trials (RCTs) was performed to determine the efficacy and safety of dexamethasone combined with other antiemetic in the prevention of PONV in patients undergoing LC. Methods A systematic literature search was conducted to identify all relevant RCTs. The primary outcome was PONV in the early period (0–3?hours, 0–4?hours, or 0–6?hours), late period (>6?hours), and the overall period (0–24?hours). Results Nine RCTs with a total of 1089 patients were included in the analysis. Pooled analysis showed that dexamethasone combined with other antiemetics provided significantly better prophylaxis than single antiemetics in the early period [odds ratio (OR): 0.34; 95% confidence interval (CI): 0.21–0.55; p ?