Design and in vitro evaluation of mucoadhesive mini tablets for nasal drug delivery of sumatriptan

摘要

The aim of the present investigation was to develop Sumatriptan Nasal Mucoadhesive Minitablets using different mucoadhesive polymers Chitosan, Carbopol 971P and Gum copal along with Methocel. Mucoadhesive minitablets of Sumatriptan were prepared by direct compression method. The minitablets were evaluated for thickness, hardness, swelling index, mucoadhesion and in vitro drug release. All postcompressional parameters were found to be within acceptable standard limits. It was observed that mucoadhesive minitablets contained polymer blend of Carbopol, Carbopol/ Chitosan , Carbopol/ Gum copal were successfully controlled the release of drug up to 7 days. The release data were fit into different kinetic models (zero order, first order and Korsemeyer- Peppas powers law equation) the mechanism of drug release was found to follow zero order release. N1 and N6 formulations were selected as optimum formulations based on evaluation studies