ANTIDIABETIC ACTIVITY OF CLERODENDRUM SERRATUM (L.) MOON LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

摘要

Objective: The present study has been undertaken to evaluate the antidiabetic activity of C. serratum leaves. Methods: The fresh leaves were collected from Khandagiri hills of Khurda distrit in the state of Odisha, India and extracted successively with n -hexane, methanol and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose loaded and Streptozotocin-induced diabetic rats along with glucose utilization potential in rat hemi-diaphragm. Results: The test extracts showed significant reduction of blood glucose level in normal, glucose loaded and Streptozotocin-induced diabetic rats and also exhibited better glucose utilization by isolated rat hemi-diaphragm. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts. Conclusion: The leaf of Clerodendrum serratum (L.) Moon is endowed with blood sugar lowering potential in both normal and diabetic rats.