EVALUATION OF HUMORAL IMMUNE RESPONSE TO FOOT-AND-MOUTHDISEASE VACCINATION IN EXPERIMENTALLY INFECTED GUINEA PIGS WITH TRYPANOSOMA EVANSI

摘要

The primary and secondary antibody responses of Trypanosoma evansi infected guinea pigs, all lacking foot-and-mouth disease (FMD) antibodies, to an inactivated FMD vaccine containing O₁ A-Mardabad and Asia₁ virus strains was evaluated. In experiment 1, guinea pigs (group A) were infected and vaccinated against FMD simultaneously. In experiment 2, guinea pigs (group B) were infected then vaccinated on posttreatmentday 7. Booster doses were injected 28 days after primary vaccination. Blood samples were obtained 21 days after primary vaccination and 15 days after the second in both experiments. Body weight gains were diminished significantly in experiment 2, whereas body weight gains of guinea pigs in experiment 1 did not differ from that in control guinea pigs. Only in experiment 2, the infected animals showed a significant suppression (P