Diagnostic value of free-to-total PSA proportion and PSA density in prostate cancer detection for prostate volumes = 100 cc

摘要

Introduction: Free to total PSA proportion (f/t FPSA) and PSA density (PSAD) are mostly used PSA derivatives for better cancer detection. In this study, we aimed to evaluate whether or not f/t PSA and PSAD had any diagnostic contribution to prostate cancer (pCa) detection in patients that had prostate volumes = 100 cc.Material and Methods: The medical records of transrectal ultrasound guided prostate biopsy performed patients were retrospectively evaluated and divided into two categories according to their prostate volumes (=100 cc). The diagnostic value of total PSA, PSAD and f/t PSA in prostate cancer detection for prostate volumes = 100 cc were statistically evaluated.Results: Among 311 patients 51 and 260 had prostate volumes =100 cc and =100 cc.Conclusions: The most significant value of our study was demonstrating the inability of pCa detection of PSAD and f/t PSA in prostate volumes =100 cc. Although larger and prospective studies are warranted to make better inferences, up to that time our results may guide clinicians in their daily practice.