Platelets’ Functional Peculiarities in Persons of the Second Mature Age with Spinal Column Osteochondrosis of the Second Degree

摘要

Introduction: Many disturbances in a body are often accompanied by some disturbance of blood parameters. Regular blood elements and, especially, platelets can play a significant role in development of dystrophic changes in any tissues. Their aggregation can influence the processes of microcirculation and metabolism in all the internals and in musculoskeletal system. Clarification of characteristics of platelet aggregation in the second mature age which very often gives clinical manifestations of osteochondrosis can help in understanding the mechanisms of its progression and the methods of its correction in having this disturbance patients. The Aim: is to estimate platelets’ aggregative activity in persons of the second mature age with spinal column osteochondrosis of the 2nd degree. Materials and Methods of Research: In this study we enrolled 37 healthy persons of both sexes of the second mature age (men 35-60 years, women 35-55 years) and also 43 persons of both sexes of the same age with osteochondrosis of the 2nd degree. We applied biochemical, hematological and statistical methods of investigation. Results: Plasma of the examined persons with spinal column osteochondrosis had increased level of acylhydroperoxides by 38.4%. It was accompanied by the rise of P-selectin in their blood by 21.8% and platelet/endothelial cell adhesion molecule 1 – by 23.9%. The level of cholesterol in platelets of persons with osteochondrosis was increased by 30.5% at lowering of common phospholipids by 19.7%. The quantity of acylhydroperoxides in their platelets was increased by 32.5%. At the same time, the persons with osteochondrosis were noted to have earlier development of platelets’ aggregation, than in the control: with collagen – by 37.4%, with ADP – by 32.3%, with rystomicin – by 42.2%. Conclusion: The persons of the second mature age with spinal column osteochondrosis of the 2nd degree are noted to have strengthening of platelets’ aggregation. It can affect the processes of microcirculation and promote the progression of osteochondrosis. These changes should be taken into account in the search of options for osteochondrosis deceleration and reducing the severity of its manifestations by application the tested therapeutic approaches because of their effect on aggregation properties of platelets.