Electrode Modification by Long-Chain, Dialkyl Disulfide Reagent Having Terminal Dinitrophenyl Group and Its Application to Impedimetric Immunosensors

摘要

A long-chain, dialkyl disulfide having a terminal dinitrophenyl (DNP) group was newly synthesized for modification of a surface of gold with chemisorbed, self-assembled organic monolayers. The resulting monolayer was characterized by infrared spectroscopy of reflection absorption spectroscopy mode, by cyclic voltammetric measurement and by electrical impedance measurement. Coupled with impedance measurements, a possible application of the modified electrode system to impedimetric immunosensors was demonstrated. The sensor gave electrical response to anti-DNP antibody at 10-103ng cm-3 concentration.