Porocarcinoma; presentation and management, a meta-analysis of 453 cases

摘要

Background porocarcinoma is a rare sort of skin cancer developing from sweat glands. Its clinical course and management are not well understood. Objectives the current meta-analysis is to address the presentation and management of porocarcinoma. Data sources Web of Science, PubMed, MEDLINE on OVID and Google scholar were searched for English-language studies published before December 1, 2016. Results The review of literature revealed 453 cases. From which 222 (49%) cases were male and female were 231 (51%). The mean age was 67.57 years. The mean duration of presentation was 5.57 years ranging from 4 days to 60 years of age. The most common site of affection is the head and neck (39.9%) followed by lower extremity (33.9%). Mass and nodule are the most common modes of presentation. Metastasis occurred at presentation in 110 (31%) cases. The most common organ to which porocarcinoma metastizes is the nearby lymph node (57.7%). Conclusions Porocarcinoma is an aggressive skin cancer. Surgery is the main modality of treatment. Systematic review registration number reviewregistry233. Highlights ? Porocarcinoma is a rare sort of skin cancer developing from sweat glands. ? Because of rarity of the problem, there is controversy regarding both presentation and management. ? The aim of the current meta-analysis is to summarize all data regarding the disease.