Antibacterial Activity of Some Non-steroidal Anti-inflammatory Drugs against Bacteria Causing Urinary Tract Infection

摘要

This study aims to evaluate the effect of NSAIDs on the activity of some antibiotics against urinary tract pathogens. Urine samples were collected and cultured on cysteine lactose electrolyte deficient (CLED) media and MICs for some antibiotics and NSAIDs were determined using Agar dilution method. The combined effects of some NSAIDs and some β-lactam antibiotics were tested on standard strains by checkerboard dilution technique. Out of 100 samples (63 female patients and 37 male patients suffering from UTIs), 122 bacterial strains were isolated. E. coli and Coagulase negative Staphylococci (CoNS) were the most common (39.3% and 26.2%, respectively), followed by S. aureus (9.8%), Klebsiella spp, Enterococcus faecalis (7.4% each), P. aeruginosa (3.2%), Streptococci, Proteus spp. (2.5% each) and Bacillus spp. (1.6%). Most strains showed high resistance against the tested antibiotics. Diclofenac sodium and indomethacin showed the lowest MIC90 against the tested strains. All the tested NSAIDs significantly lowered the MICs of antibiotics against the tested bacteria and FICIs for these combinations ranged from 0.004 to 0.5. In conclusion, NSAIDs significantly increased the therapeutic activity of the tested antibiotics showing good synergistic effect.