Assessment of Anemia and Thrombopathy in Eastern Sudanese Patients with End Stage Renal Disease

摘要

Renal manifestations are becoming a very important health problem in the developing world. In Sudan, the new cases account for about 70-140 thousand of inhabitants per year. Leading to reduced quality of life, these manifestations have negative social and economic impact on the population. This cross-sectional study was conducted in March 2016 to evaluate the anemia and thrombopathy in patients with end stage renal disease (ESRD) in Port Sudan hospital for surgery and hemodialysis, Red Sea State, Sudan. The study enrolled 70 patients, of whom 56 (80%) were males and 14 (20%) were females with the mean age being 51 years along with 70 healthy apparently adult subjects as control group of whom 53 (76%) were males and 17 (24%) were females with the mean age being 31 years. Unlike the control group, 51 (72%) of patients had anemia according to WHO criteria. Severe anemia (Hemoglobin concentration less than 7 g/dl) was detected in 28.6% of patients. Severe anemia has been more frequently (21.4%) in males than in females (7.1%). Likewise, the patient group showed a statistically significant decrease in platelet count (197.700±57.367) as compared to that of the control group (221.357±65.00) (P<0.024). In contrast, mean platelet volume (MPV) in the patient group showed a statistically significant increase (11.7±1.66) as compared to that of the control group (10.43±0.98) (P< 0.006). Thrombocytopenia was seen in 14.3% of patients. To conclude, this data could indicate that anemia and thrombopathy seen among these patients are attributed to the underlying renal impairment. This study recommends that all patients with unclear cause of anemia and/or thrombopathy should be checked for renal manifestations.