Formulation and Evaluation of Dosage form of Raupya (Silver) bhasma for colon targeted drug delivery

摘要

ABSTRACT The potential of guar gum as a film coating material for colon targeted delivery of raupyabhasma is assessed in this study. The granules was prepared by mixing raupyabhasma, guar gum and xanthan gum which was coated by guar gum and pH-sensitive polymer eudragit FS30D sequentially around drug-loaded granules. The outer eudragit FS30D coating defends the system against gastrointestinal environment and dissolves rapidly in distal small intestine, where a lumen pH of over 7 triggers the dissolution of the enteric polymer. The inner guar gum coating works as a time-controlled retardant and offers additional protection of the granules until it is degraded by microbes at the proximal colon. In vitro results indicate that guar gum followed by eudragit FS30D coating is a feasible coating material to achieve colon specific drug delivery. Keywords: Colon targeting, Microbially triggered drug delivery to colon, Polysaccharide based drug delivery, Colon targeted drug delivery, Silver nanoparticles, Bhasma etc.