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Viscum Album Versus Bleomycin for Pleurodesis among Patients with Malignant Pleural Effusion

机译:恶性胸腔积液患者的黏膜白蛋白对博莱霉素治疗胸膜固定术

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OBJECTIVE: To compare between mistletoe(Viscum album) and bleomycin as chemical agents for pleurodesis in malignant pleural effusions. METHODS: In this study 50 patients with pathologically confirmed, symptomatic, malignant pleural effusion irrespective of the primary tumor were studied at Suez Canal University hospital in the period of 3 years from January 2009 to December 2012. Patients were divided into 2 groups; 25 patients each: group A(pleurodesis with Mistletoe using 100mg – 5 ampoules-repeated two or three times, injected every other day) and group B(pleurodesis with Bleomycin1 iu/kg average-4 ampoules-or maximally 60 units). follow-up included postero-anterior and lateral chest radiography done after one week, month and 3 months. RESULTS: Most of the patients among both groups show complete remission defined as no effusion detected within four weeks of pleurodesis (72% and 56% among bleomycin and Viscum groups respectively). Significant difference was found between both groups. Recurrences were more frequent among group A (20% versus 8% in group B), P < 0.05. Hospital stay was shorter in the bleomycin group of patients, with a mean of (6.2) day. CONCLUSION: Both bleomycin and Viscum album are effective and safe agents for chemical pleurodesis, however bleomycin has some advantages over Viscum album due to its lower incidence of failure, and being more economic and for the shorter hospital stay.
机译:目的:比较槲寄生和博来霉素作为恶性胸腔积液胸膜固定术的化学药剂。方法:从2009年1月至2012年12月,在苏伊士运河大学医院对50例经病理证实,有症状,恶性胸腔积液的原发性肿瘤患者进行了研究,时间为3年。每位25名患者:A组(使用100mg – 5安瓿对槲寄生进行胸膜固定术,重复2或3次,隔天注射一次)和B组(Bleomycin分别使用博来霉素1 iu / kg平均4安瓿或最多60个单位)。随访包括一个星期,一个月和三个月后进行的后前路和外侧胸片。结果:两组中的大多数患者显示出完全缓解,定义为在胸膜固定术后的四周内未发现积液(博来霉素和Viscum组分别为72%和56%)。两组之间存在显着差异。 A组的复发率更高(B组为20%,B组为8%),P <0.05。博来霉素组患者的住院时间较短,平均为(6.2)天。结论:博来霉素和Viscum Album都是有效且安全的化学性胸膜固定药,然而,博来霉素比Viscum Album具有某些优势,因为它的失败率更低,更经济并且住院时间更短。

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