The Survival of Extra nodal Non-Hodgkin’s Lymphoma Patients in the West of Iran

摘要

Background: Extra nodal Non-Hodgkin’s Lymphoma (NHL) is a heterogeneous disease in regard to geographical, ethnic, anatomic, etiological, and morphological diversities. The aim of study is evaluation of survival in extra nodal NHL patients for the first time in western Iran. Patients and Methods: Between of 2002 to 2014, fifty patients with extra nodal NHL referred to Our Clinic. We checked age, sex, histopathology reports, anatomic sites and survival for them. One representative Material of patients with diffuse large B-cell lymphoma (DLBL), Malt lymphoma, FL, SLL, anaplastic lymphoma and Burkitt’s lymphomas was re-classified after revision. The overall survival (OS) was plotted by GraphPad Prism 5 software. Results: The median age at diagnosis for the patients was 50 years (range, 13-77 years) that 26 patients (52%) had age≤ 50 years. Twenty-seven patients (54%) were male. Involvement anatomic sites were GIT, bone, abdominal, testis, skin, CNS, spleen, maxilla and adrenal gland for 19 patients(38%), 15(30%), 5(10%), 4(8%), 2(4%), 2(4%), 1(2%), 1(2%) and 1(2%), respectively. The 3-year, 5-year and 10-year survival rates are 70%, 62.2% and 60.8%, respectively. Conclusion: The OS in this study is higher than other studies and the median age is lower. Also, GIT is the most common site of involvement in extra nodal lymphomas in Middle East.