Topical Adapalene 0.1% Gel versus Topical Combination of (Tretinoin 0.025% and Erythromycin 4%) Gel in Treatment of AcneVulgaris(A Split Face Comparative Study)

摘要

This study was conducted to compare the efficacy of topical adapalene 0.1% gel versus a combined formula of topical tretinoin 0.025% and erythromycin 4% gel in the treatment of mild to moderate inflammatory acne vulgaris. Thirty six patients with inflammatory acne vulgaris (papules and pustules) were enrolled in the study. A split face method was used inwhich each patient was instructed to use a combined gel formula (tretinoin 0.025% and erythromycin 4%) on the right side of the face and adapalene 0.1% gel on the left side. Each patient was instructed to use the same amount of both gels at night. The duration of therapy was 6 weeks.Only 30 patients completed the study, 23 females and 7males, their ages ranged from 14-33 (20.66±4.79) years. After 3 weeks of treatment the mean percent of reduction of lesions of the right and left sides was 67.86% and 50.41% respectively. The difference was statistically significant p-value <0.0001. After 6 weeks it reduced to 91.69% and 87.36% respectively. The difference was not significant p-value = 0.065. Few patients had mild erythema and dryness at both sides.In conclusion, both formulae have comparable efficacy.