A Novel 2D Graphical Representation and its Application in the Similarities/Dissimilarities Analysis of Protein Sequences

摘要

In this study, a novel 2D graphical representation of protein sequences is proposed based on the physicochemical feature pK2 of amino acids first and then, on the basis of the newly given 2D graphical representation, a new concept of feature appearance model is introduced to analyze the similarity/dissimilarity of protein sequences. Finally, Theoretical and simulation results show that the newly proposed method is effective in similarities/dissimilarities analysis of protein sequences.