Synthesis, Spectral Characterization and Antimicrobial Activity of Schiff Bases and Their Mixed Ligand Metal Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

摘要

In the present study a new series of Copper(II), Nickel(II) Cobalt(II) and Zinc(II) complexes with two newly synthesized Schiff base ligands N-[(E)-(5-Methylfuran-2-yl)methylidene]-ethane-1,2-diamine (MFMEDA) and N-p-hydroxybenzalidine-2-aminopyridine (HBAPy) have been prepared. The Schiff bases MFMEDA and HBAPy ligands were synthesized by the condensation of 5-methyl furfural with ethylene-1,2-diamine and p-hydroxybenzaldehyde with 2-aminopyridine respectively. The ligands and their metal complexes have been characterized by FT-IR, Mass, ~(1)H NMR, UV–Vis., elemental analysis and Thermal gravimetric analysis. The Schiff base and their metal complexes were tested for antimicrobial activity against gram positive bacteria Staphylococcus aureus and gram negative bacteria Escherichia coli, Salmonella typhimurium and fungus Aspergillus nidulence, Candida albicans and Saccharomyces cerevisiae using Broth Dilution Method.