Antibacterial Assay of Two Synthesized Dithiocarbamate Ligands

摘要

Dithiocarbamates are compounds that bind strongly and selectively to so many metal ions. They readily form chelates with all transition metal ions through their two donor sulphur atoms. In this study, two derivatives of dithiocarbamate (sodium phenyldithiocarbamate and sodium cyclohexyldithiocarbamate) were studied to determine their effectiveness in the treatment of diseases caused by the tested organisms. Antibacterial activities of these ligands were carried out using the disc diffusion method. Antibacterial activities were exhibited by sodium phenyldithiocarbamate and sodium cyclohexyldithiocarbamate, against Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa, Proteus mirabilis, and Salmonella typhi. Minimum inhibitory concentration was 15 mg/ml for sodium phenyldithiocarbamate with zone of inhibition range of 8.5 mm - 19 mm and 30 mg/ml for sodium cyclohexyldithiocarbamate with zone of inhibition range of 7.7 mm - 16.3 mm. The ligands can compete favourably with gentamycin which served as the reference drug.