Synthesis, Characterization and Antimicrobial Activity of V(IV), Ag(I) and Cd(II) Complexes with Mixed Ligands Derived from Sulfamethoxazole and Trimethoprim

摘要

A series of new metal complexes were prepared by mixing 4-amino-N-(5-methylisoxazole-3-yl)-benzene -sulfonamide (L1) as a chelating ligand in the presence of the co-ligand trimethoprim (L2), with Vanadium (V), Cadmium (Cd) and Silver (Ag) ions in alcoholic medium. The complexes were characterized in solid state by using flame atomic absorption, elemental analysis C.H.N.S, FT-IR, UV-Vis Spectroscopy, conductivity and magnetic susceptibility measurements. Tetrahedral geometry was suggested for CdL1L2, AgL1L2 complexes, while VL1L2 complex has a square pyramidal. The ligand L1, with the metal ions, was clearly behaving as a bidentate through O and N atoms of sulfonylamid, while L2 behaves as a bidentate ligand through N and N atoms for all the complexes. Conductivity has shown that all the preparations complexes are ionized, and the nature of bonding between the metal ion and the donor atoms of the ligands was demonstrated by calculating the ligand field parameters by using suitable Tanaba-Sugano diagrams. Biological activity of V(IV), Cd(II), Ag(I), TMP, and SMX, with different concentrations (50, 100, 250, 500, and 1000)ppm, were studied respectively, complexes with chelating ligand and co-ligand were evaluated against Staphylococcus aureus , Pseudomonas aeruginosa and Escherichia coli , after incubating for 24hr at 37oC. Results showed that L1 and L2 enhance effect of (V) against growth of (Staph. aureus and E. coli ) with concentration (50, 100, 250, 500, and 1000)ppm, while Ps. aeruginosa was sensitized to (Cd) and (Ag) with concentration more than (250)ppm, after incubated for 24hr at 37oC. Whereas, the SMX is exposed to a failure in its efficiency against Staph. aureus , Ps. aeruginosa , and E. coli .