Synthesis of Metal–Organic Frameworks MIL-101(Cr)-NH2 Containing Phosphorous Acid Functional Groups: Application for the Synthesis of N-Amino-2-pyridone and Pyrano [2,3-c]pyrazole Derivatives via a Cooperative Vinylogous Anomeric-Based Oxidation

摘要

In the current paper, we successfully developed and used metal–organic frameworks (MOFs) based on MIL-101(Cr)-NH_(2) with phosphorus acid functional groups MIL-101(Cr)-N(CH_(2)PO_(3)H_(2))_(2). The synthesized metal–organic frameworks (MOFs) as a multi-functional heterogeneous and nanoporous catalyst were used for the synthesis of N -amino-2-pyridone and pyrano [2,3-c ]pyrazole derivatives via reaction of ethyl cyanoacetate or ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes. The final step of the reaction mechanism was preceded by a cooperative vinylogous anomeric-based oxidation. Recycle and reusability of the described catalyst MIL-101(Cr)-N(CH_(2)PO_(3)H_(2))_(2) were also investigated.