Immunomodulatory and Therapeutic Prospective of a Protein Supplement with Vitamins and Selenium (Multimune) against Chicken Infectious Anaemia in Broiler Chicks

摘要

Chicken infectious anaemia virus (CIAV) is a well-established cause of generalized lymphoid atrophy accumulating severe immunosuppression subsequent to infection. In this study, we assessed the role of a protein supplement with vitamins and selenium (Multimune) against the CIAV infection in broiler chicks. Experiment was performed on 60 day-old broiler chicks grouped into 3 groups of 20 birds in each and all the birds were vaccinated against Newcastle Disease (ND) and infectious bursal disease (IBD). The chicks of group I served as healthy control and other 2 group chicks (group II and III) were exposed to CIAV (104.5 TCID50/0.1 ml). The Multimune was fed for 3 weeks to chicks of group III @1 gm / 10 birds. Successively, all the birds were examined for ND antibody titres, various haematological and biochemical parameters, organ: body weight ratios, and mean live body weight at weekly interval until 35th day of the study. The chicks of group II showed significant decline in the count of erythroid and myeloid cells, mean live body weight and organ: body weight ratios of lymphoid organs, and ND antibody titres, whereas upturn was observed in enzyme activities and uric acid values. In contrast, the immunosuppression was less severe in (group III in comparison to group II chicks. The haematological and biochemical parameters, mean live body weight and organ body weight ratios were significantly (P<0.05) higher in Multimune supplemented chicks. Present study highlights the use of Multimune as an effective immunomodulating agent in immune suppressed CIAV affected birds with reduced virus pathogenicity, enhanced immune responses and safeguards the virus prompted ill effects on bird’s growth performances