Experiment of aerosol-release time for a novel automatic metered dose inhaler:

摘要

The objective of this study was to evaluate the aerosol-release time in the development of a new automatic adapter for metered dose inhaler. With this device, regular manually operated metered dose inhalers become automatic. During the study, an inhalation simulator was designed and tested with the newly developed mechatronic system. By adjusting the volume and the pressure of the vacuum tank, most human inhalation waveforms were able to simulate. As an example, regular quick-deep and slow-deep waveforms were matched within reasonable accuracy. Finally, with the help of dynamic image processing, the aerosol-release time (Tr) was carefully measured and fully discussed, including the switch-on time (Ts), the mechatronics-hysteresis (Tm) and the intentional-delay (Ti). Under slow-deep inhalation condition which is suitable for metered dose inhaler medicine delivery, the switch-on flow-rate could reach as low as 10?L/min, and the corresponding switch-on time was approximately 0.20?s. While the mechatronics-hy...