Lactic Acid Bacteria as Mucosal Delivery Vaccine

摘要

Mucosal surfaces of the body provide a congenial entry portal for all the known and emerging infective pathogenic microbes. Therefore, it is imminent that vaccination strategies need to be evolved for developing vaccines that are capable of hindering the entry of microbes through mucosal surfaces. The present day conventional vaccination strategies, though effective against some pathogens, seems ineffective due to certain drawbacks such as being ineffectual in generating immune response at mucosal surfaces and also of the difficulties experienced during administration of vaccine. Hence, novel strategies, such as development of oralasal mucosal vaccines vectored by probiotic microbes, can be thought of as an alternative as they are effective in inducing protective immunity at the site of infection, capable of eliciting systemic and mucosal immunity and moreover, easy to administer. This review outlines the efficacy of probiotic mucosal vaccines in modulating the immune system, particularly emphasizing on two major lactic acid bacilli as candidates for mucosal vaccine delivery vehicles in livestock and poultry