Relationship with immunhistochemical staining extent of CD47 and histopathologic features of bladder tumor

摘要

Introduction It has been shown that CD47 is an important diagnostic and prognostic marker in manycancer types. However, the relationship between CD47 and bladder tumor stage has not been shownin previous studies. To the best of our knowledge, this is the first study investigating the associationof CD47 with stages of bladder cancer.Material and methods Surgical specimens of 175 patients were included in the study. The CD47 stainingassessment was performed in the following categories; none, focal, moderate and diffuse. The statisticsof the study were tested using t-test and analysis of variance.Results We demonstrated much less CD47 staining extent in Ta tumor pathology compared to T1and T1+T2+T3+T4 tumor pathology (p = 0.034 and p = 0.016, respectively). We also showed thatthe average value of CD47 staining extent with CIS+ was significantly higher compared to CIS–among NMIBC (p = 0.0248). However, no significant differences in CD47 staining pattern wereobserved in the following study groups: high vs. low-grade tumors in non-muscle invasive bladdercancer (NMIBC); MIBC (T2–T4) vs. NMIBC; lymph node involvement (N1–N3) vs. non-lymph nodeinvolvement (N0) in MIBC (T2–T4).Conclusions Our study demonstrated that CD47 might have a critical role in the progression of Ta to T1stage. Furthermore, we showed that CD47 is highly expressed in CIS+ NMIBC compared to CIS- NMIBC.Thus, differentiating stages with the help of this new potential marker may help clinicians treat bladdertumors better. Future studies to determine the role of CD47 on pathophysiology, diagnosis and prognosisof bladder tumor are warranted.