The Viability of Intralipid optical Phantom for Developing Noninvasive Blood Glucometer

摘要

This research article focuses on the critical analysis about the viability of Intralipid optical tissue resembling phantoms for developing noninvasive blood glucometer. Utilization of the intralipid phantoms in Photo-Acoustic Spectroscopy (PAS), Pulsed Photo-Acoustic (PA) Techniques, OCT (Optical Coherence Tomography), TOF (Time of Flight) based Monte Carlo Simulations, Ultrasound-Modulated Optical Techniques, Polarization Techniques, Occlusion Spectroscopy, Raman Spectroscopy for noninvasive glucometer development has been discussed in this research article. Moreover, Standard Oral Glucose Tolerance Test (OGTT) conducted over 03 normal human subjects by our indigenously developed MUS-IR (Modulated Ultra Sound-Infra Red) unit for determination of blood glucose levels has been reported here. Actually, the blood plasma samples have been collected during the fasting stage of the subjects and every 30minutes after 75gm glucose consumption up to the total time period of 2hr and 30minutes. Blood plasma samples have been mixed with intralipid phantom samples and processed through indigenously developed MUS-IR unit for respective sample glucose concentration determinations. Moreover, for cross validation of results obtained, readings have been compared with the findings of the Digital spectrophotometer respectively. Outcome of the results indicates intralipid phantom samples serves as a feasible option in invitro experimentations for designing and developing noninvasive glucometer.