The Toxicity Effect of Cerium Oxide Nanoparticles on Blood Cells of Male Rat

摘要

In this work, we investigated the toxicity effect of cerium oxide nanoparticles on blood cells of male Rat. The cerium oxide nanoparticles synthesized and morphological properties of it such as UV-Vis spectrum characterization and Microscopic characterization (SEM&TEM) were investigated. The hematological studies were performed on 40 male rats that divided into five octet groups. After treatment rats with different concentrations of cerium oxide nanoparticles, the results showed that a decrease of overall mean Hematocrit and mean number of Red blood cells (RBC) was seen in all experimental groups; but the white blood cells (WBC) compare to control group, had only a linear increase from first group to third group and in the fourth group, namely the concentrations of 200ppm cerium oxide nanoparticles, the white blood cells was severely reduced and even reached lower than of control group.