Evaluation of Salivary Calcium and Phosphorous Concentration Before and After Chewing CPP-ACP Containing Chewing Gum

摘要

Objective: To estimate the salivary concentration of calcium and phosphorous before and after chewing sugar free chewing gum containing Casein phosphopeptide-Amorphous calcium phosphate (CPP-ACP) namely RecaldentTM and to determine the extent and duration to which the salivary levels of calcium and phosphorus remain retained in saliva after chewing the CPP-ACP containing gum. Materials and Method: A non-randomized clinical trial was conducted among 30 randomly selected students aged 18 – 25 years. Unstimulated saliva was collected by draining method before and at different intervals after chewing CPP-ACP chewing gum for 20 minutes. These samples were tested for calcium and phosphorous concentration. Data were analyzed using SPSS version 17 software using Repeated measure Anova and Students paired t-test and percentage difference. Results: The mean calcium concentration of saliva increased significantly immediately after (Ai) chewing CPP-ACP containing chewing gum with the mean difference of 22% when compared to the baseline (B). A significant increase in the calcium concentration of saliva as compared to the baseline (B) was observed for up to 2 hours after chewing the gum, whereas a decrease in the phosphorus concentration in saliva for up to 1 hour after chewing the gum was observed when compared to baseline (B). Conclusion - CPP as an ACP carrier significantly increases the calcium concentration of the saliva, thereby facilitating remineralization.