A new rabies vaccine with an experimental adjuvant for domestic animals

摘要

The authors had developed a new experimental adjuvant based on squalene and its efficacy was tested on target domestic animals - cats and dogs by means of different rabies vaccines. In this experiment the authors compared the immune response on the rabies vaccine without adjuvant and with aluminium adjuvant or experimental squalene adjuvant, respectively. The level of rabies antibodies was determined by rapid fluorescence focus inhibition test on days 14, 30, 90 and 450 (dogs), and on days 14, and 30 (cats), respectively. The rabies antibodies level on day 14 still did not reache the protection level determined by WHO. On day 30 each of the vaccines induced an adequate response, while the most effective seemed to be the vaccine with experimental squalene adjuvant. On day 450 the antibodies level decreased, but the average level was over the protection value, when the experimental squalene-adjuvanted vaccine was used. The level of rabies antibodies did not achieve the protection value in 2 from 10 dogs in this group. There is an open question, if it is sufficient to use only one dose of rabies vaccine for safe primovaccination of young animals.