Immunohistohemical and Pathological Studies of Rabies in Brain of Domestic Animals in Pakistan

摘要

Rabies is a horrifying neglected infectious disease and a severe underestimated global health issue.Approximately,70,000 people died of rabies every year primarily in Asia and Africa,where dog rabies is enzootic.The aim of present study was to investigate the pathological and immunohistological detection of rabies in brains of domestic animals of district Faisalabad,Pakistan.A total of 192 brain samples,consisting of six samples of each species (Sheep,goat,cow and buffalo)were collected from eight towns including (Madina,Jaranwala,Iqbal,Layallpur,Sumandri.Tandlianwala,Chak jhumra,and Jinnah).Crossly brains of the affected animals were severely congested and edematous microscopically,the cerebrum and cerehellum showed characteristic lesions including degenerative and necrotic changes in the glial cells and neurons,rod shape neurons,perivascular cuffing with characteristic Babe's nodule and gliosis.