.INFEC?II FUNGICE INVAZIVE: FACTORI DE RISC ?I EVOLU?IE LA PACIEN?II CU HEMOPATII MALIGNE

摘要

Invasive fungal infections are infectious complications with an increasing incidence, raising countless problems as regards diagnosis and treatment in children with malignant diseases. Objective. The analysis of invasive fungal infections in children with malignant hemopathies. Material and method. We underwent a retrospective analysis of invasive fungal infections on a lot of 132 patients with malignant hemopathies, treated in Pediatric Clinic no 2 of Cluj-Napoca in the period 2001-2010. Results. The incidence of invasive fungal infections was 9.8% of the total number of infectious episodes. We noted correlations between invasive fungal infections, prolonged severe neutropenia (p 0.000) and, respectively, antibiotherapy (0.000). Episodes were diagnosed as “possible” (60.7%), “probable” (21.4%) and “proven” (17.9%). Most frequent etiologies were Aspergillus and Candida spp. Mortality due to invasive fungal infections was of 14.3% and chemotherapy delays had a median of 20 days. Conclusions. It is of strict necessity to introduce efficient methods of prevention, diagnosis and treatment of invasive fungal infections in children with malignant hemopathies.