Assessment of TGF-β and IL10 levels in human brucellosis

摘要

The recent study assessed TGF-β and IL-10 as immunosuppressive cytokines of the cellmediated immunity (CMI) against Brucella in the serum of some brucellosis patients.Serum from 15 patients and 15 healthy individuals were obtained, and then cytokineconcentrations above were investigated. Concentrations of TGF-β induced in the serum ofacute patients (89.73 ± 15.55 ng/ml) were higher than healthy group (58.86 ± 17.89 ng/ml,P < 0.0001). While, no significant differences were found in the concentration of IL-10between two groups. Based upon the findings of our study, the contribution of thesecytokines to the pathobiology of infection had been shown. Therefore, assessment ofimmunosuppressive cytokines as TGF-β and IL-10 levels may be a potential diagnosticstrategy for patients with brucellosis.