The clinical significance of the anti-RA33 level in patients with rheumatoid arthritis

摘要

SUMMARY Objective: The early diagnosis of Rheumatoid Arthritis (RA) is of due significance for the prevention of possible damage to the joint tissue by means of treatment. Laboratory tests are very important for monitoring RA activity and for the evaluation of the patients’ response to the treatment. Rheumatoid factor, so far the most commonly used test for the cases with suspected RA, is not a specific parameter despite its sensitivity to RA. The measurement of other autoantibodies might be helpful to the diagnosis particularly for the cases with low RF titer or with suspected diagnosis. The measurement of anti-RA33 autoantibodies is one of the tests used in the diagnosis of the RA cases. The present study was conducted to compare anti-RA33 levels of healthy individuals with long-term RA cases and to evaluate the value of anti-RA33 test for the RA diagnosis. Method: Total 40 patients (28 female and 12 male) identified with RA at least for the last five years according to the classification criteria of American College of Rheumatology (ACR) reviewed in 1987 and 40 healthy controls included in the present study. Results: AntiRA-33 level was determined as 12.47±4.97 U/mL for the patients with RA and as 1.96±1.82 U/mL for the healthy controls, and there is no statistically significant difference between the groups. Conclusions : As a result AntiRA-33 level was evaluated in RA patients and no difference was found compared to control group. Keywords: Rheumatoid Arthritis, Rheumatoid Factor, Anti-RA33 ?ZET Ama?: RA tan?s?n?n erken konulmas?, tedavi ile eklem dokusundaki hasar?n ?nüne ge?ilebilmesi a??s?ndan ?ok ?nemlidir. Laboratuar testleri, RA aktivitesinin izlenmesinde ve tedaviye yan?t?n de?erlendirilmesinde olduk?a ?nemlidir. RA ?üphesi olan vakalarda bugüne kadar en yayg?n kullan?lan test romatoid fakt?rdür, RA’ya duyarl? olmas?na ra?men ?zgül olmayan bir parametredir. ?üpheli vakalarda ya da dü?ük RF sevyeli vakalarda otoantikor ?l?ümü tan? koymada yard?mc? olabilir. Anti RA-33 otoantikor ?l?ümü RA’l? hastalarda kullan?lan otoantikor testlerinden biridir. Bu ?al??man?n amac? sa?l?kl? bireyler ile RA’l? bireylerin Anti-RA 33 seviyesini kar??la?t?rmak ve Anti-RA 33 seviyesinin RA tan?s?nda ?nemini de?erlendirmektir. Y?ntem: American College of Rheumatology (ACR) RA klasifikasyon kriterlerine g?re belirlenmi? hastal?k süresi en az iki y?l olan 28 i bayan,12 si erkek toplam 40 RA’li hasta ile ayn? say?da kontrol grubu sa?l?kl? ki?iler ?al??maya al?nd?. Bulgular: RA’li hasta grubunda AntiRA-33 düzeyi 12,47±49,76 U/ml, sa?l?kl? kontrol grubunda AntiRA-33 düzeyi 1,96±1.82 U/ml olup gruplar aras? istatiksel olarak bir fark bulunmad?. Sonu?: RA’l? hastalarda AntiRA-33 düzeyi ile sa?l?kl? kontrol grubu aras?nda anlaml? bir fark bulunamad?.