Evaluation of EuIIa??based positive contrast enhancement after intravenous, intraperitoneal, and subcutaneous injections

摘要

EuIIa??based contrast agents offer physiologically relevant, metala??based redox sensing that is unachievable with GdIIIa??based contrast agents. To evaluate the in vivo contrast enhancement of EuII as a function of injection type, we performed intravenous, intraperitoneal, and subcutaneous injections in mice. Our data reveal a correlation between reported oxygen content and expected rates of diffusion with the persistence of EuIIa??based contrast enhancement. Biodistribution studies revealed europium clearance through the liver and kidneys for intravenous and intraperitoneal injections, but no contrast enhancement was observed in organs associated with clearance. These data represent a step toward understanding the behavior of EuIIa??based complexes in vivo. Copyright ?? 2016 John Wiley & Sons, Ltd.