Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis

摘要

Background The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood. Methods We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results DSS-resistant BALB/c mice were characterized by low levels of IFN- γ and TNF- α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4~(+)CD25~(+)FoxP3~(+) T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis. Conclusions The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.