The Effects of Fluoxetine and Buspirone on Self-Injurious and Stereotypic Behavior in Adult Male Rhesus Macaques

摘要

Theeffectsoftwoserotonergicagents#8212;fluoxetine,aserotonin(5-HT)reuptakeinhibitor,andbuspirone,a5-HT1subxmlns="http://pub2web.metastore.ingenta.coms/"a/subagonist#8212;onratesofself-injuriousandstereotypicbehaviorwereexaminedin15adultmaleMacacamulatta.Allanimalsreceivedaplacebofor2weeksfollowedbyeitherbuspironeorfluoxetinefor12weeks.Behaviorwasmonitoredusingafocalsamplingtechniquethroughoutthestudyandfor2weekspost-study.Cerebrospinalfluid(CSF)samplesandbodyweightswereobtainedpre-study,attheendsofplaceboandtreatmentphases,andpost-study.Fluoxetineandbuspironeweresignificantlyeffectiveinreducingratesofself-bitingduringtreatmentweeks1to8andself-directedstereotypicbehaviorduringweeks5to12andpost-treatment.Nosignificanteffectofeithertreatmentonhair-plucking,stereotypicpacing,saluting,orheadtossingwasidentified.Thedurationofneutralbehaviorincreased,andratesofscratchingandyawningdecreasedinthebuspirone-treatedcondition.Inthefluoxetine-treatedcondition,ratesofyawning,scratching,andself-directedgroomingwerehigheroverallcomparedwiththoseofbuspirone-treatedanimals,andratesofscratchingincreasedsignificantly(P0.05)inweeks9to12;thesefindingssuggestthatanimalsinthefluoxetine-treatedconditionexperiencedhigherlevelsofanxietythroughoutthestudy.Inbothtreatmentconditions,concentrationsofCSF5-HIAA(5-HTmetabolite)weresignificantlylower(P0.05)thanplaceboconcentrations.Fluoxetineandbuspironemaybeefficaciousfortreatmentofself-injuriousandself-directedstereotypicbehaviorinmacaques.Furtherstudiesarerequiredtodeterminetheoptimaldosagesandtreatmentlength.