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Abdominal Distension and Escherichia coli Peritonitis in Mice Lacking Myeloid Differentiation Factor 88

机译:缺乏髓样分化因子88的小鼠的腹胀和大肠杆菌性腹膜炎

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Herewedescribethegrossandmicroscopicfindingsofnaturallyoccurring,#946;-hemolyticEscherichiacoliperitonitisinB6.129-Myd88suptm1Aki/supmaleandfemalemice.Overapproximately5mo,10homozygousmutantmicedeficientinmyeloiddifferentiationfactor88(C57BL/6strain;maleandfemale)thathadnotbeenusedinresearchprotocolsdevelopedrapid-onsetabdominalswellingassociatedwithcopiousviscousascites.Eachmousedevelopedananteriorperitonitis,primarilyinvolvingtheparietalperitoneumandthevisceralsurfaceofthespleen,liver,diaphragm,andstomach.Inflammationwasconfinedtotheorgansurfaces,withnoindicationofsepticemiaorgrosslyapparentgastrointestinalperforationorothertissuecompromisethatwouldinitiateperitonitis.Peritonitiswaslikelyattributabletocompromisedantibacterialinnateimmunity;cohoused,similarlyimmunodeficientlittermatesdidnotdevelopsimilarclinicalsigns.Anunusualfindinginallcaseswasmesothelialcellhyperplasiaandhypertrophy.Althoughtheunderlyinginnateimmunedeficiencyaccountsformuchoftheobservedpathology,theremarkablemesothelialcellmorphologyandtheepisodicnatureoftheperitonitisinsomelittermatesandnotothersremainunexplained.
机译:Herewedescribethegrossandmicroscopicfindingsofnaturallyoccurring,#946; -hemolyticEscherichiacoliperitonitisinB6.129-MYD88 tm1Aki maleandfemalemice.Overapproximately5mo,10homozygousmutantmicedeficientinmyeloiddifferentiationfactor88(C57BL / 6strain; maleandfemale)thathadnotbeenusedinresearchprotocolsdevelopedrapid-onsetabdominalswellingassociatedwithcopiousviscousascites.Eachmousedevelopedananteriorperitonitis,primarilyinvolvingtheparietalperitoneumandthevisceralsurfaceofthespleen,肝,隔膜,andstomach.Inflammationwasconfinedtotheorgansurfaces,withnoindicationofsepticemiaorgrosslyapparentgastrointestinalperforationorothertissuecompromisethatwouldinitiateperitonitis.Peritonitiswaslikelyattributabletocompromisedantibacterialinnateimmunity ;尽管没有发现,但在所有情况下都发现间皮细胞增生和肥大。腹膜炎的体细胞形态学和发作的某些特征,还有其他尚未解释。

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