Identification and Analysis of Novel Tandem Repeats in the Cell Surface Proteins of Archaeal and Bacterial Genomes Using Computational Tools

摘要

We have identified four novel repeats and two domains in cell surface proteinsencoded by theMethanosarcina acetivoransgenome and in some archaeal andbacterial genomes. The repeats correspond to a certain number of amino acid residuespresent in tandem in a protein sequence and each repeat is characterized by conservedsequence motifs. These correspond to: (a) a 42 amino acid (aa) residue RIVW repeat;(b) a 45 aa residue LGxL repeat; (c) a 42 aa residue LVIVD repeat; and (d) a 54 aaresidue LGFP repeat. The domains correspond to a certain number of aa residues ina protein sequence that do not comprise internal repeats. These correspond to: (a) a200 aa residue DNRLRE domain; and (b) a 70 aa residue PEGA domain. We discussthe occurrence of these repeats and domains in the different proteins and genomesanalysed in this work.