Extraintestinal Campylobacteriosis in Rhesus Macaques (Macaca mulatta)

摘要

TwocasesofclinicaldiseaseassociatedwithextraintestinalCampylobacterinfectionwererecentlyencounteredinrhesusmacaques(Macacamulatta).Thefirstcasewasthatofa3-y-old,male,rhesusmacaqueexperimentallyinfectedwithSIV,whopresentedwithabdominalpainandamidabdominalmassandwaseuthanized.Pathologyfindingsincludedanabscesswithinthemedianliverlobe,fibrinopurulentperitonitis,andintestinalserositiswithisolationofCampylobacterfetusfromtheblood,liver,andthehepaticabscess.Thesecondcasewasthatofa1-mo-old,female,rhesusmacaquewhodiedwithnoapparenthistoryofillness.Grosspathologyfindingsincludedthinbodyconditionanddiarrheicstainingoftheperineum;histologically,acutemultifocalhepatitiswithintralesionalbacteriawasnoted.Campylobactercoliwasisolatedfromtheliverandcolon.ExtraintestinalCampylobacterinfectionisuncommoninhumans,usuallyoccurringinimmunocompromisedsubjectsandmostcommonlymanifestingasbacteremia.ExtraintestinalCampylobacterinfectionsinanimalsarerarebuthavebeenassociatedwithbacteremiaandcholecystitis.ThemacaquespresentedherewereeitherimmunocompromisedduetoSIVinfection(case1)ormorevulnerableduetoyoungage(case2).ThesefactorslikelycontributedtotheextraintestinalspreadofCampylobacter.