Fatigue and Sleep during Cancer and Chemotherapy: Translational Rodent Models

摘要

Thefrequentoccurrenceoffatigueanddisturbedsleepincancersurvivorsandthenegativeeffectofthesesymptomsonqualityoflifeandclinicaloutcomeunderscoretheneedtoidentifymechanismsthatcausecancer-relatedfatigue,withaviewtowarddevelopingmoreeffectivetreatmentsforthisproblem.Humanstudiesoffatigueanddisturbedsleeparelimitedbyhighinter-individualgeneticandenvironmentalvariability,difficultieswithbehavioralorreportingcompliance,andthesubjectivenatureoftheproblems.Althoughanimalmodelsalsomustovercomethebarrierofassessingfatigueandsleepdisturbanceintheabsenceofobviousobjectiveclinicalmarkers,animalstudiesareeasiertocontrolandstandardizethanarestudiesofpeople.Moreover,animalmodelsarecrucialtotheidentificationandunderstandingofunderlyingdiseasemechanisms.Thisreviewdescribestheneedfor,thefeasibilityof,andseveralpossibleapproachestomeasuringfatigueinanimalmodelsofcancerandtorelatingsuchmeasurestodisturbedsleep,immunefunction,andotherpotentialmechanisms.Developingandusinganimalmodelstobetterunderstandfatigueanddisturbedsleeprelatedtocanceranditstreatmenthasanenormouspotentialtoexpandtheknowledgebaseandfosterhypothesesnecessaryforthefuturedevelopmentandtestingofinterventions.