...
首页> 外文期刊>Comparative Medicine >Monkey B Virus (Cercopithecine herpesvirus 1)
【24h】

Monkey B Virus (Cercopithecine herpesvirus 1)

机译:猴B病毒(Cercopithecine疱疹病毒1)

获取原文

摘要

Macaquesareaparticularlyvaluablenonhumanprimatemodelforawidevarietyofbiomedicalresearchendeavors.Bvirus(Cercopithecineherpesvirus1;BV)isan#945;-herpesvirusthatnaturallyinfectsconventionalpopulationsofmacaques.SeriousdiseaseduetoBVisrareinmacaques,butwhentransmittedtohumans,BVhasapropensitytoinvadethecentralnervoussystemandhasafatalityrategreaterthan70%ifnottreatedpromptly.ThesevereconsequencesofhumanBVinfectionsledtotheinclusionofBVintheoriginalNIHlistoftargetvirusesforeliminationbydevelopmentofspecificpathogen-freerhesuscolonies.Inmacaquesandespeciallyinhumans,diagnosisofBVinfectionisnotstraightforward.Furthermore,developmentandmaintenanceoftrueBVspecificpathogen-freemacaquecolonieshasprovendifcult.InthisoverviewwereviewthenaturalhistoryofBVinmacaques,summarizewhatisknownaboutthevirusatthemolecularlevel,andrelatethisinformationtoproblemsassociatedwithdiagnosisofBVinfectionsanddevelopmentofBV-freemacaquecolonies.
机译:Macaquesareaparticularlyvaluablenonhumanprimatemodelforawidevarietyofbiomedicalresearchendeavors.Bvirus(Cercopithecineherpesvirus1; BV)ISAN#945; -herpesvirusthatnaturallyinfectsconventionalpopulationsofmacaques.SeriousdiseaseduetoBVisrareinmacaques,butwhentransmittedtohumans,BVhasapropensitytoinvadethecentralnervoussystemandhasafatalityrategreaterthan70%ifnottreatedpromptly.ThesevereconsequencesofhumanBVinfectionsledtotheinclusionofBVintheoriginalNIHlistoftargetvirusesforeliminationbydevelopmentofspecificpathogen-freerhesuscolonies.Inmacaquesandespeciallyinhumans,diagnosisofBVinfectionisnotstraightforward.Furthermore,developmentandmaintenanceoftrueBVspecificpathogen-freemacaquecolonieshasprovendifcult.InthisoverviewwereviewthenaturalhistoryofBVinmacaques,summarizewhatisknownaboutthevirusatthemolecularlevel,andrelatethisinformationtoproblemsassociatedwithdiagnosisofBVinfectionsanddevelopmentofBV-freemacaquecolonies。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号