Isosexual Precocious Puberty and Polycystic Ovary Syndrome

摘要

A 13-year-old girl presented with isosexual precocious puberty and later developed polycystic ovary syndrome (PCO). Laboratory examination revealed high levels of plasma luteinizing hormone (LH), estrone and androgens. Because of significantly high levels of plasma dehydroepiandrosterone sulfate (DHEAS) and hyperresponsiveness to adrenocorticotropin (ACTH) of DHEAS, it appeared that the PCO was caused by not only hypothalamic-pituitary dysregulation of gonadotropin secretion but also by hypersecretion of adrenal androgens.